A new review explains how TERRA-driven R-loops at telomeres can either protect chromosome ends or fuel replication stress, ...

Watson and Crick's discovery of DNA structure in 1953 revealed a possible mechanism for DNA replication. So why didn't ...

Ultra-deep long-read sequencing has delivered the first telomere-to-telomere sequence of the non-Mendelian ribosomal DNA ...

In the 1930s, Hermann Muller was the first researcher to note that the ends of chromosomes had unique properties. Muller ...

New findings suggest the end-replication problem, an old standby of biology textbooks, is twice as intricate as once thought. Half a century ago, scientists Jim Watson and Alexey Olovnikov ...

The human genetic blueprint is deceptively simple. Our genes are tightly wound into 46 X-shaped structures called chromosomes. Crafted by evolution, they carry DNA and replicate when cells divide, ...

We depend on our cells being able to divide and multiply, whether it’s to replace sunburnt skin or replenish our blood supply and recover from injury. Chromosomes, which carry all of our genetic ...

A new article analyzes in depth the physical problems associated with DNA packaging that have often been neglected in structural models of chromosomes. The study demonstrates that the multilaminar ...

Cell biologists from RIKEN have provided an unprecedented glimpse into the distinctive features of an unusual chromosome—the inactivated X chromosome copy carried by every female cell. The findings ...

The Regenerative Medicine Project at our institute is advancing therapeutic strategies for various diseases by introducing a ...